1196 FRAILTY AND ARTERIAL STIFFNESS - THE ROLE OF OXIDATIVE STRESS AND INFLAMMATION (FRAXI STUDY)

Abstract Introduction There is an association between frailty and arterial stiffness. However, stiffness does not uniformly correlate with the spectrum of states. Both oxidative stress inflammaging contribute to vascular aging. are no human studies exploring links stiffness, stress, frailty. Our objective investigate as predictors Methods An observational longitudinal cohort study will be used examine inflammation in 50 older adults (≥70 years) clinical scores (CFS) ≤6 over six months. All measurements taken at baseline. Frailty assessment include hand-grip strength, timed-up go test, mini-mental state examination, geriatric depression scale sarcopenia using body composition Tanita®. Arterial carotid-femoral pulse wave velocity (cfPWV) carotid-radial (crPWV) Complior (Alam Medical, France). CAVI device measure Cardio-ankle index ankle brachial (ABI). Oxidative blood markers nitrotyrosine (NT) 8-hydroxy-2’-deoxyguanosin (8-oxo-dG) high-sensitive C-reactive protein (hs-CRP) interlukin-6(IL-6) measured baseline 6-months along lipid profile glycated haemoglobin. Data Analysis Descriptive statistics for continuous data means standard deviations normality distributed variables or medians inter-quartile ranges skewed used. Participants categorised into CFS 1-3, 4-6. Categorical use frequencies comparison groups. Change groups 6 months compared paired t-test. Simple linear regression done measures, inflammation, biomarkers. Significance p<0.5. Conclusion This inform a larger, multi-centre further interplay frailty, biomarkers, parameters. funded by BGS.